
Aging and Apoptosis Research:
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Rajani
R.J. Shelke and Christiaan Leeuwenburgh: Life-long calorie restriction
(CR) increases expression of apoptosis repressor with a caspase recruitment
domain (ARC) in the brain. The FASEB Journal Express Article 10.1096/fj.02-0803fje
Published online January 2, 2003
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Selman,
C., Kendaiah, S., Gredilla, R., and Leeuwenburgh, C. (2003) Increased hepatic
apoptosis during short-term caloric restriction is not associated with
an enhancement in caspase levels. Exp Gerontol 38, 897-903
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Selman,
C., Gredilla, R., Phaneuf, S., Kendaiah, S., Barja, G., and Leeuwenburgh,
C. (2003) Short-term caloric restriction and regulatory proteins of apoptosis
in heart, skeletal muscle and kidney of Fischer 344 rats. Biogerontology
4, 141-147
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Phaneuf, S., and C. Leeuwenburgh. 2002. Cytochrome c release from mitochondria
in the aging heart: a possible mechanism for apoptosis with age. Am J Physiol
Regul Integr Comp Physiol. 282:R423-30.
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Dirks,
A., and C. Leeuwenburgh. 2002. Apoptosis in skeletal muscle with aging.
Am J Physiol Regul Integr Comp Physiol. 282:R519-27.
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Pollack,
M and C. Leeuwenburgh. Aging and Apoptosis; The Role of Mitochondria. Journal
of Gerontology, November, 2001
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Phaneuf,
S., and C. Leeuwenburgh. Apoptosis and exercise. Med. Sci. Sports Exerc.,
Vol. 33, No. 3, 2001, pp. 393–396
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Pollack
M, Phaneuf S, Dirks A, Leeuwenburgh C: The Role of Apoptosis in the Normal
Aging Brain, Skeletal Muscle, and Heart. Ann N Y Acad Sci 2002;959:93-107.
Apoptosis and Doxorubicin
Toxicity:
Green, P., and C. Leeuwenburgh. Mitochondrial dysfunction is an early indicator
of doxorubicin-induced apoptosis. Biochimica et Biophysica Acta (Molecular
Basis of Disease).
Childs, A., S. Phaneuf, A. Dirks, T. Phillips, C. Leeuwenburgh. Doxorubicin
treatment in vivo causes cytochrome c release and cardiomyocyte apoptosis,
as well as increased mitochondrial efficiency, superoxide dismutase activity,
and bcl-2/bax ratio. Cancer Research. 62, 4592-4598, 2002.