Research on Aging, Exercise and Oxidative Stress

• Payne, A. M., Dodd, S. L., and Leeuwenburgh, C. (2003) Life-long calorie restriction in Fischer-344 rats attenuates age related loss in skeletal muscle specific force and reduces extracellular space. J Appl Physiol.
• Judge, S., Judge, A., Grune, T., and Leeuwenburgh, C. (2003) Short-term caloric restriction decreases cardiac mitochondrial oxidant production and antioxidant enzyme activities but increases protein carbonyl content. Am J Physiol Regul Integr Comp Physiol.
• Leeuwenburgh, C. (2003) Role of apoptosis in sarcopenia. J Gerontol A Biol Sci Med Sci 58, M999-M1001
• Drew, B. R., and Leeuwenburgh, C. (2003) Method for measuring ATP production in isolated mitochondria; ATP production in brain and liver mitochondria of Fischer-344 rats with age and caloric restriction. Am J Physiol Regul Integr Comp Physiol
• David Julian and Christiaan Leeuwenburgh.  (2004).  Linkage between insulin and the free radical theory of aging.  Am J Physiol Regul Integr Comp Physiol 286, R20-R21
• Drew, B., Phaneuf, S., Dirks, A., Selman, C., Gredilla, R., Lezza, A., Barja, G., and Leeuwenburgh, C. (2003) Effects of aging and caloric restriction on mitochondrial energy production in gastrocnemius muscle and heart. Am J Physiol Regul Integr Comp Physiol 284, R474-R480.
• Selman, C., and Leeuwenburgh, C. (2003) The role of Id2 and apoptosis during skeletal muscle remodeling. Am J Physiol Regul Integr Comp Physiol 284, R538-539.
• Drew B, Leeuwenburgh C: Aging and the Role of Reactive Nitrogen Species. Ann N Y Acad Sci 2002;959:66-81.
• Leeuwenburgh, C., and J.W. Heinecke. 2001. Oxidative stress and antioxidants in exercise. Curr Med Chem. 8:829-38. 2001
• Pollack, M and C. Leeuwenburgh. Molecular Mechanisms of Oxidative Stress and Aging: Free radicals, aging, antioxidants, and disease. Handbook of Oxidants and Antioxidants in Exercise. p 881-926, C.K. Sen, L. Packer and O. Hanninen, editors. Chapter 30: Elsevier Science, 1999.
• Leeuwenburgh C, Hansen PA, Holloszy JO, Heinecke JW.  Hydroxyl radical generation during exercise increases mitochondrial protein oxidation and levels of urinary dityrosine. Free Radic Biol Med 1999;27(1-2):186-92
• Leeuwenburgh C, Hansen PA, Holloszy JO, Heinecke JW.  Oxidized amino acids in the urine of aging rats: potential markers for assessing oxidative stress in vivo.  Am J Physiol 1999;276(1 Pt 2):R128-35
• Leeuwenburgh C, Wagner P, Holloszy JO, Sohal RS, Heinecke JW. Caloric restriction attenuates dityrosine cross-linking of cardiac and skeletal muscle proteins in aging mice. Arch Biochem Biophys 1997, 1;346(1):74-80.
• Leeuwenburgh, C., P. Hansen, A. Shaish, J.O. Holloszy, and J.W. Heinecke. 1998. Markers of protein oxidation by hydroxyl radical and reactive nitrogen species in tissues of aging rats. Am J Physiol. 274:R453-61.

Research on Aging, Exercise and Oxidative Stress: More Papers

• Adams, S., P. Green, R. Claxton, S. Simcox, M.V. Williams, K. Walsh, and C. Leeuwenburgh. 2001. Reactive carbonyl formation by oxidative and non-oxidative pathways. Front Biosci. 6:A17-24.
• Pennathur, S., J.D. Wagner, C. Leeuwenburgh, K.N. Litwak, and J.W. Heinecke. 2001. A hydroxyl radical-like species oxidizes cynomolgus monkey artery wall proteins in early diabetic vascular disease. J Clin Invest. 107:853-60.
• Leichtweis, S., C. Leeuwenburgh, J. Bejma, and L.L. Ji. 2001. Aged rat hearts are not more susceptible to ischemia-reperfusion injury in vivo: role of glutathione. Mech Ageing Dev. 122:503-18.

Crowley JR, Yarasheski K, Leeuwenburgh C, Turk J, Heinecke JW.  Isotope dilution mass spectrometric quantification of 3-nitrotyrosine in proteins and tissues is facilitated by reduction to 3-aminotyrosine.Anal Biochem 1998 May 15;259(1):127-35